Combine the scenic Texas flare of Palo Duro Canyon and historic Route 66 and you have the Holiday Inn Hotel Amarillo. Located on Interstate 40 in the middle of the Texas Panhandle, we are minutes from everything including the Amarillo Airport, the Amarillo Medical District with free scheduled shuttle, the world famous Big Texan Steak Ranch, one of a kind Cadillac Ranch, international head quarters for AQHA, amusement park Wonderland, Amarillo Globe News Center, Civic Center, Amarillo College, the Tri-State Fair Grounds and we are, of course, the home of West Texas A&M University athletics! Kick your boots off in our 236 guest rooms and Texas inspired public areas. Go back in time to our Route 66, 1950s theme restaurant Bristols Caf?. Take a dip in our relaxing indoor swimming pool, or join some friends at our watering hole, Bristols Bar or eat in our restaurant. Texas hospitality is what you'll find here… but only at the Holiday Inn I-40 East of Amarillo.